ABSTRACT
Background: In Ayurveda, several herbs and formulations are available for the treatment of Urolithiasis.However, they are not systematically evaluated for their safety, efficacy, indication and limitations.Herbmed Plus is one such herbal formulation that has been known for the management of urinary tractdisorders. An attempt has been made to evaluate its efficacy on Urolithiasis.Objective: To evaluate the efficacy and safety of Herbmed Plus in urolithic rats.Materials and methods: A total of 60 Wistar albino rats were used for this study. The male and female ratswere divided into five groups: disease control, test (dose 90 mg/kg), standard I (Cystone), standard II(Alkaston insta) and normal control (six in each group). Urolithiasis was induced using ethylene glycol0.75% in drinking water for 28 days. The rats with urinary oxalate crystals were dosed with oral test orstandard treatments for 28 days.Results: All the animals appeared normal and showed no clinical signs of toxicity. None of the groups reported mortality or adverse effect on body weight and food consumption. The treatment with test drugshowed improvement in the SGPT level and urine output (5.4 vs 3.47 mL/24 h). A drastic reduction in numberof crystals were observed in male 0.5 vs 22 and female rats 0 vs 22.7 in test and disease group. The kidneylactate dehydrogenase, alkaline phosphatase, urinary phosphorus and calcium oxalate level decreased in thetest and standard drug groups as compared to disease groups. Microscopy of the urine samples showedreduction in the number of crystals after treatment compared to the urolithic group. Increase in citrate levelsin urine in all the treatment groups indicated anti-urolithiatic activity. The test group showed a 69.70% recovery in males and 47.57% recovery in female rats compared to the disease control group.Conclusion: Herbmed Plus showed a significant reduction in oxalate synthesizing enzymes suggestinganti-urolithiatic activity and anti-inflammatory and regenerative property in cellular injury caused bycrystal deposits
ABSTRACT
Background: Urolithiasis is a growing problem worldwide. Many a times, asymptomatic stones are keptunder observation. Many herbal preparations are available for the same, but they lack proper scientificdocumentation.Objective: To study the anti-urolithiatic effect of an herbal preparation, Subap Plus (IP) capsules in patients with asymptomatic renal calculi of size ranging from 4 to 9 mm.Material and methods: This was a prospective, randomized, double-blind, placebo-controlled clinical trialconducted in a tertiary care hospital in Pune, India.Patients with asymptomatic renal calculi of 4e9 mm size were randomized (1:1, block randomization) toone of the group Subap Plus (treatment group) or placebo (placebo group). The study outcome includedchange in visual analog scale (VAS), change in the surface area and density of calculi and their expulsion.Statistical analysis was performed using student's t-test and Chi-square test.Results: A total of 120 patients were screened and 84 were enrolled who met the eligibility criteria, ofwhich 65 patients completed the trial (treatment, n ¼ 34; placebo, n ¼ 31). The VAS score significantlydecreased in the treatment group (6.9e1.8) than placebo group (7.2e6.8) (p < 0.001). The surface areaand density were decreased by 47.58% (p < 0.008) and 43.01% (p < 0.001), respectively, in the treatmentgroup than the placebo group. The expulsion of calculi was significantly higher in the treatment groupthan placebo group (20.59 vs. 3.23%, p < 0.03).Conclusion: Patients treated with herbal formulation showed better expulsion rate and reduction insurface area and density than the placebo group.© 2018 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).